Gout
ӿ
, uric acid ( ߡ ), , , , , disabling chronic tophaceous gout, , , .
, , . serum proteins cell receptors, ( , microtophus) ( - ) ( ) - , immunoglobulin G - IgG , 1 interleukin (IL)-1 cytokines 6 8, neutrophil chemotactic factors, tumor necrosis factor (TNF)-alpha, Neutrophil phagocytosis .
damaged neutrophils recoating of urate crystals, anti-inflammatory cytokines, transforming growth factor (TGF)-beta.
: 1% .
: , .
.
chronic tophaceous gout
.
, , .
, , , , ( insulin resistance, , , , ) , , .
.
13.6 1000 , 6.4 1000 .
( ) , .
20 .
, , 30 , purine metabolism, metabolic syndrome, , , Tophi 10 .
( ) Cyclosporin A - - .